Karyotypic findings in chronic myeloid leukemia cases undergoing treatment.
Indian J Hum Genet
;
2012 Jan; 18(1): 66-70
Artigo
em Inglês
| IMSEAR
| ID: sea-139445
ABSTRACT
BACKGROUND:
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells. MATERIALS ANDMETHODS:
In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.RESULTS:
Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.CONCLUSION:
This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Piperazinas
/
Pirimidinas
/
Cromossomo Filadélfia
/
Feminino
/
Humanos
/
Masculino
/
Células-Tronco Hematopoéticas
/
Leucemia Mieloide de Fase Crônica
/
Criança
/
Hospitais
Tipo de estudo:
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2012
Tipo de documento:
Artigo
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