Intravitreal bevacizumab for treatment of choroidal neovascularization associated with osteogenesis imperfecta.
Indian J Ophthalmol
;
2012 May; 60(3): 229-231
Artigo
em Inglês
| IMSEAR
| ID: sea-139480
ABSTRACT
A 12-year-old girl, diagnosed of osteogenesis imperfecta, presented with sudden visual loss in the left eye. Investigations revealed an active choroidal neovascular membrane. She underwent treatment with intravitreal Bevacizumab (1.25 mg/0.05 ml). Follow-up at 1 month revealed the development of lacquer crack running through the macula, underlying the fovea. The patient received two re-treatments at 1-month intervals, following which the choroidal neovascularization (CNV) regressed completely. However, further progression of lacquer cracks was noted. At the last follow-up, 6 months following the last injection, the fundus remained stable and vision was maintained at 20/200. Considering the natural history of the disease and the increased risk of rupture of the Bruch's membrane in such eyes, the possible complication of a lacquer crack developing must be borne in mind, before initiating treatment.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Osteogênese Imperfeita
/
Feminino
/
Humanos
/
Angiofluoresceinografia
/
Criança
/
Seguimentos
/
Progressão da Doença
/
Neovascularização de Coroide
/
Inibidores da Angiogênese
/
Fator A de Crescimento do Endotélio Vascular
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Ophthalmol
Ano de publicação:
2012
Tipo de documento:
Artigo
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