Sugammadex - A short review and clinical recommendations for the cardiac anesthesiologist.
Ann Card Anaesth
;
2010 Sept; 13(3): 206-216
Artigo
em Inglês
| IMSEAR
| ID: sea-139533
ABSTRACT
This review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that binds a chemical complex with rocuronium and vecuronium, by which the neuromuscular blockade is quickly reversed. It is free of any clinical side-effects and doses of 2 mg/kg or more reliably reverse neuromuscular blockade within 5-15 min, depending on the depth of the neuromuscular blockade. Doses below 2 mg/kg should be avoided at any time because of the inherent risk of recurarization. Sugammadex should not replace good clinical practice - titration of neuromuscular blocking drugs to clinical needs and objective monitoring of neuromuscular blockade in the operating room or intensive care unit. Neuromuscular transmission should be determined in all patients before sugammadex is considered and 5 min after its administration to ensure that extubation is performed with normal neuromuscular transmission.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Ensaios Clínicos como Assunto
/
Ensaios Clínicos Fase III como Assunto
/
Ensaios Clínicos Fase II como Assunto
/
Ensaios Clínicos Fase I como Assunto
/
Bloqueio Neuromuscular
/
Gama-Ciclodextrinas
/
Relação Dose-Resposta a Droga
/
Interações Medicamentosas
/
Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Ann Card Anaesth
Ano de publicação:
2010
Tipo de documento:
Artigo
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