GST null genotype and antioxidants: Risk indicators for oral pre-cancer and cancer.
Artigo
em Inglês
| IMSEAR
| ID: sea-139737
ABSTRACT
Objectives:
This study was undertaken to detect the gene polymorphism of detoxification enzymes and estimate the antioxidant enzyme status in patients with oral cancer, oral leukoplakia and oral submucous fibrosis (OSF). Materials andMethods:
The GSTM1 and GSTT1 gene polymorphism was evaluated using polymerase chain reaction; the antioxidant enzyme was estimated using biochemical methods. Statistical analyses were performed using student t-test and odds-ratio to estimate relative risk (RR).Results:
The RR at 95% confidence interval (CI) for GSTM1 and GSTT1 was statistically significant for all groups. The mean values of glutathione were significantly raised in all groups. The mean values of ceruloplasmin and malonaldehyde was statistically significant among cancer and OSF patients but was insignificant in smokers and cases with leukoplakia.Conclusion:
Several genes perform the same function which implies the need to test for several genetic polymorphisms to identify individuals at high risk. The level of antioxidant enzymes correlate with the degree of oxidative damage. The need for further studies is emphasised.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fibrose Oral Submucosa
/
Polimorfismo Genético
/
Lesões Pré-Cancerosas
/
Valores de Referência
/
Idoso
/
Humanos
/
Ceruloplasmina
/
Neoplasias Bucais
/
Estudos de Casos e Controles
/
Razão de Chances
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2009
Tipo de documento:
Artigo
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