16S rRNA-based detection of oral pathogens in coronary atherosclerotic plaque.
Artigo
em Inglês
| IMSEAR
| ID: sea-139857
ABSTRACT
Background:
Atherosclerosis develops as a response of the vessel wall to injury. Chronic bacterial infections have been associated with an increased risk for atherosclerosis and coronary artery disease. The ability of oral pathogens to colonize in coronary atheromatous plaque is well known.Aim:
The aim of this study was to detect the presence of Treponema denticola, Porphyromonas gingivalis and Campylobacter rectus in the subgingival and atherosclerotic plaques of patients with coronary artery disease. Materials andMethods:
Fifty-one patients in the age group of 40-80 years with coronary artery disease were selected for the study. DNA was extracted from the plaque samples. The specific primers for T. denticola, C. rectus and P. gingivalis were used to amplify a part of the 16S rRNA gene by polymerase chain reaction. Statistical Analysis Used Chi-square analysis, correlation coefficient and prevalence percentage of the microorganisms were carried out for the analysis.Results:
Of the 51 patients, T. denticola, C. rectus and P. gingivalis were detected in 49.01%, 21.51% and 45.10% of the atherosclerotic plaque samples.Conclusions:
Our study revealed the presence of bacterial DNA of the oral pathogenic microorganisms in coronary atherosclerotic plaques. The presence of the bacterial DNA in the coronary atherosclerotic plaques in significant proportion may suggest the possible relationship between periodontal bacterial infection and genesis of coronary atherosclerosis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Idoso de 80 Anos ou mais
/
Doença da Artéria Coronariana
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
DNA Bacteriano
/
RNA Ribossômico 16S
/
Distribuição de Qui-Quadrado
/
Reação em Cadeia da Polimerase
Tipo de estudo:
Estudo diagnóstico
Limite:
Aged80
Idioma:
Inglês
Ano de publicação:
2010
Tipo de documento:
Artigo
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