Lycopene in the management of oral lichen planus: A placebo-controlled study.
Artigo
em Inglês
| IMSEAR
| ID: sea-140101
ABSTRACT
Context Oxidative stress has been implicated in the pathogenesis of lichen planus, and a lower level of lycopene has been reported in erosive and atrophic oral lichen planus (OLP) patients. However, its efficacy in the management of OLP has not been reported. Aim:
This study was designed to assess the efficacy of systemic lycopene in the management of OLP. Settings andDesign:
This prospective, randomized, double-blind, placebo-controlled study was done in the Oral Medicine Department of a postgraduate teaching dental hospital in India. Materials andMethods:
Thirty symptomatic OLP patients, randomly divided into two groups of 15 each, were administered lycopene 8 mg/day and an identical placebo, respectively, for 8 consecutive weeks. Burning sensation using visual analogue scale and overall treatment response using Tel Aviv-San Francisco scale were recorded at every visit. The data obtained were analyzed statistically using Wilcoxon Rank test, Mann-Whitney and Fischer's Exact test.Results:
A higher (84%) reduction in burning sensation was seen in lycopene than in the placebo group (67%). All 15 (100%) patients in the lycopene group showed 50% or more benefit and 11 (73.3%) patients showed 70-100% benefit, while this number was only 10 and 4 (26.7%), respectively, in the placebo group.Conclusion:
Lycopene was very effective in the management of OLP, and oxidative stress may have a role in disease pathogenesis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Placebos
/
Medição da Dor
/
Indução de Remissão
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Carotenoides
/
Método Duplo-Cego
/
Estudos Prospectivos
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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