Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study.
Artigo
em Inglês
| IMSEAR
| ID: sea-140163
ABSTRACT
Objective:
To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF). Materials andMethods:
Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied.Results:
Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls.Conclusion:
There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fibrose Oral Submucosa
/
Fenótipo
/
Areca
/
Ratos
/
Fatores de Tempo
/
Feminino
/
Humanos
/
Masculino
/
Contagem de Células
/
Linhagem Celular
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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