Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients.
Indian J Biochem Biophys
;
2012 Apr; 49(2): 97-100
Artigo
em Inglês
| IMSEAR
| ID: sea-140224
ABSTRACT
Diabetes and renal insufficiency are interrelated metabolic disorders closely associated with redox homeostasis disturbances. The aim of this study was to compare the activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of hypertensive diabetic patients with or without renal insufficiency with normal healthy control subjects. In both groups of diabetic patients, blood glucose level and the content of glycosylated hemoglobin (HbA1c) were higher than in the control group. However, CuZnSOD activity was significantly higher than control only in hypertensive diabetic patients with renal insufficiency. Our results suggest that disturbances in superoxide homeostasis do correlate with long-term complication in diabetes, i.e. diabetic renal insufficiency and hypertension.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Superóxido Dismutase
/
Glicemia
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Catalase
/
Estudos de Casos e Controles
/
Complicações do Diabetes
/
Eritrócitos
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2012
Tipo de documento:
Artigo
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