CALLA negative precursor B lymphoblastic leukemia with MLL gene translocation and an unusual FISH signal pattern.
Indian J Pathol Microbiol
;
2011 Jan-Mar 54(1): 176-179
Artigo
em Inglês
| IMSEAR
| ID: sea-141949
ABSTRACT
Rearrangements of the mixed lineage leukemia (MLL) gene at 11q23 commonly occur in infants with CALLA negative B lymphoblastic leukemia (B-ALL). Most often, these are detected by conventional karyotyping; however, fluorescent in-situ hybridization (FISH) with the help of a dual-color break-apart probe is used to identify cryptic translocations. When there is an MLL gene translocations the usual FISH signal pattern is 1 red-1 yellow fusion signal pattern We present a case of an infant with CALLA negative precursor B-ALL with a characteristic translocations t(4;11) (q21;q23),however,with an unusual MLL FISH signal pattern.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Translocação Genética
/
Humanos
/
Masculino
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Hibridização in Situ Fluorescente
/
Proteína de Leucina Linfoide-Mieloide
/
Lactente
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2011
Tipo de documento:
Artigo
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