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Study of bone marrow changes in antiretroviral naive human immunodeficiency virus-infected anemic patients.
Indian J Pathol Microbiol ; 2011 Jul-Sept 54(3): 542-546
Artigo em Inglês | IMSEAR | ID: sea-142039
ABSTRACT

Background:

Bone marrow changes are common throughout the course of HIV infection. There is scanty data addressing this issue in Indian subcontinent. The present study was aimed at characterizing the bone marrow changes in the antiretroviral naive HIV-infected Indian patients with anemia. Materials and

Methods:

This was a nonrandomized cross-sectional observational study undertaken over a period of 2 years. Forty-six randomly selected patients with documented anemia served as the study population. None of them was on any antiretroviral therapy or suffering from any known causes of anemia. All the patients underwent thorough evaluation, including bone marrow examination.

Results:

Majority of the patients had normocytic-normochromic anemia (63%), in tune with the available data. In most of the cases bone marrow was hypercellular (63.04%), although in a significant proportion it was found to be hypocellular (19.57%). Erythropoiesis was suppressed in 36.96% of patients. Dysplastic changes involving isolated cell lines ranged from 13.04% to 45.65%, dysmegakaryopoiesis being the most common, followed by dyserythropoiesis. Marrow plasmacytosis was detected in 23.91% of patients. No statistically significant correlation was detected in between immunological status (CD4 count) and marrow cellularity, myelodysplastic changes or marrow plasmacytosis. In a fair number of cases bone marrow examination aided in the diagnosis of opportunistic infections.

Conclusions:

Bone marrow changes are common in Indian HIV-infected anemic population, particularly in the advanced stages of the disease. HIV infection should be considered in the differential diagnosis of patients with secondary myelodysplasia or unexplained bone marrow changes.
Assuntos

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Medula Óssea / Feminino / Humanos / Masculino / Infecções por HIV / Prevalência / Estudos Transversais / Adulto / Anemia / Pessoa de Meia-Idade Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Idioma: Inglês Revista: Indian J Pathol Microbiol Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Medula Óssea / Feminino / Humanos / Masculino / Infecções por HIV / Prevalência / Estudos Transversais / Adulto / Anemia / Pessoa de Meia-Idade Tipo de estudo: Estudo observacional / Estudo de prevalência / Fatores de risco Idioma: Inglês Revista: Indian J Pathol Microbiol Ano de publicação: 2011 Tipo de documento: Artigo