Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype.
Indian J Pathol Microbiol
;
2011 Jul-Sept 54(3): 591-593
Artigo
em Inglês
| IMSEAR
| ID: sea-142052
ABSTRACT
Primary cardiac lymphoma (PCL) is a rare and fatal disorder. It may often mimic other common cardiac tumors like cardiac myxoma because of similarities in the clinical presentation. We report a case of PCL of diffuse large B-cell type, in a 38-year-old, immunocompetent male who presented with superior vena cava syndrome that was excised as a myxoma. Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype. After four cycles of Rituximab with CHOP (cyclophosphamide, hydroxydaunorubicin, Oncovin, and prednisolone) the tumor regressed completely but the patient had a relapse and subsequently succumbed to the disease confirming the aggressive nature. The aggressive behavior of PCL may be possibly linked to its ABC-like origin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenótipo
/
Recidiva
/
Proteínas Repressoras
/
Vincristina
/
Síndrome da Veia Cava Superior
/
Humanos
/
Masculino
/
Prednisona
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Imuno-Histoquímica
/
Linfócitos B
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2011
Tipo de documento:
Artigo
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