Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma.
Indian J Pathol Microbiol
;
2011 Jul-Sept 54(3): 599-602
Artigo
em Inglês
| IMSEAR
| ID: sea-142055
ABSTRACT
Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin's lymphoma that frequently involves nodal and extranodal sites. The presence of leukemic phase in ALCL is extremely rare and occurs exclusively with ALK1-positive ALCL. We describe two patients with ALK1-positive ALCL who developed a leukemic phase with rapid progression of the disease. Immunophenotypic pattern assessed on peripheral blood by flow cytometry revealed CD45, CD30, and CD25 positivity in both cases but NPM-ALK1 was expressed in only one case. Both patients developed leukemic phase as a terminal event of the disease and we share the immunophenotypic features of both cases.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Leucócitos Mononucleares
/
Leucemia Linfoide
/
Criança
/
Adolescente
/
Antígenos Comuns de Leucócito
/
Receptores Proteína Tirosina Quinases
/
Linfoma Anaplásico de Células Grandes
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2011
Tipo de documento:
Artigo
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