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Primary hyperparathyroidism in children and adolescents.
Indian J Pediatr ; 2010 Feb; 77(2): 175-178
Artigo em Inglês | IMSEAR | ID: sea-142496
ABSTRACT
Objective. Primary hyperparathyroidism (PHPT) in children and adolescents is a rare condition. Awareness should improve in order to lower threshold for screening and allow intervention before serious and permanent sequelac occur. Methods. A retrospective analysis of 15 children and adolescents with PHPT (age <20 yr) seen in our clinic between 1993 and 2006. Results. Mean age of patients was 17.73 yr (Range - 13-20, Male-3 Female-12). Average duration of symptoms was 18.87 (range 0-48) mo. Clinical features at presentation included bone pain (86.67%), proximal myopathy (46.67%), bony deformities (53.33%), fractures (60%), palpable osteitis fibrosa cystica (33.3%), renal calculi (40%), palpable neck swelling (13.3%) and acute pancreatitis (6.67%). None had positive family history or features suggestive of multiple endocrine neoplasia (MEN). After biochemical confirmation, tumor was localised in all prior to surgery. Histopathology confirmed adenoma in all cases. Post-operative hungry bone syndrome occurred in 33.3%. Conclusion. PHPT is more common in females. Presentation of the disease is similar to their adult counterparts except for more severe bone disease and less severe renal disease. MEN and familial non-MEN PHPT do not constitute a major cause of pediatric PHPT as against to worldwide data. The incidence of hyperplasia as a cause of PHPT is rare in our pediatric population.
Assuntos

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Osteíte Fibrosa Cística / Feminino / Humanos / Masculino / Neoplasia Endócrina Múltipla / Comorbidade / Criança / Incidência / Prevalência / Estudos Retrospectivos Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2010 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Osteíte Fibrosa Cística / Feminino / Humanos / Masculino / Neoplasia Endócrina Múltipla / Comorbidade / Criança / Incidência / Prevalência / Estudos Retrospectivos Tipo de estudo: Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2010 Tipo de documento: Artigo