Association of microsatellite instability and chronic obstructive pulmonary disorder in isocyanate-exposed population of Bhopal.
Indian J Hum Genet
;
2012 May; 18(2): 172-176
Artigo
em Inglês
| IMSEAR
| ID: sea-143266
ABSTRACT
Context Survivors of the Bhopal gas disaster still suffer from various respiratory ailments. We examined the effects of exposures among a cross-section of current residents suffering from COPD by ISSR-PCR. Aims:
Molecular screening of the gas-affected population of Bhopal with COPD for microsatellite instability due to exposure of MIC. Settings andDesign:
The isocyanate-exposed population of Bhopal city suffering from chronic obstructive pulmonary disorder. Materials andMethods:
Inter-(SSR) analysis was used to characterize microsatellite instability in 52 MIC victims of Bhopal, suffering from COPD using (CA) 8 RG and (CA) 8 R[Y-Q] primer. Statistical Analysis Used Association analyses were performed using regression analysis.Results:
The study on the MIC-affected population in Bhopal showed weak association between microsatellite instability and age (r = + 0.37); exposure distance from site (r = −0.44); and smoking status(r = + 0.12); while regression analysis of the above parameters displayed supporting evidence.Conclusions:
The high prevalence of smoking coupled with aging and poor living habits threatens, to further increase COPD incidences among this population, highlighting the need for enhanced screening efforts.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Idoso de 80 Anos ou mais
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Análise Fatorial
/
Isocianatos
/
Repetições de Microssatélites
/
Adulto
/
Doença Pulmonar Obstrutiva Crônica
Limite:
Aged80
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2012
Tipo de documento:
Artigo
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