16S rDNA-based metagenomic analysis of human oral plaque microbiota in patients with atherosclerosis and healthy controls.
Indian J Med Microbiol
;
2012 Oct-Dec; 30(4): 462-466
Artigo
em Inglês
| IMSEAR
| ID: sea-144011
ABSTRACT
To address the question if an altered oral microbiota is associated with atherosclerosis. Twenty patients suffering from atherosclerosis and 10 controls were recruited. Clinical oral, medical and laboratory investigations were performed. Oral bacteria were collected and 16S rDNA was sequenced following Single strand conformation polymorphism.(SSCP) Probing pocket depths in patients were significantly elevated. The oral microbiota of patients and controls were dominated by Fusobacterium (16%/17%), Streptococcus (21%/14%), Prevotella (10%/12%), Enterococcus (12%/12%), Porphyromonas (8%/7%), TM7 (0%/7%) and Veillonella (6%/7%). Differences in diversity were not significant between groups. The pathology of atherosclerosis may not be related to significant qualitative changes of the oral microbiota.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pacientes
/
Streptococcus
/
Veillonella
/
Humanos
/
DNA Bacteriano
/
RNA Ribossômico 16S
/
Grupos Controle
/
Prevotella
/
Placa Dentária
/
Metagenômica
Tipo de estudo:
Pesquisa qualitativa
Idioma:
Inglês
Revista:
Indian J Med Microbiol
Assunto da revista:
Microbiology
Ano de publicação:
2012
Tipo de documento:
Artigo
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