p 53 codon 72 polymorphism in stomach and colorectal adenocarcinomas in Iranian patients.
Indian J Cancer
;
2010 Jan-Mar; 47(1): 31-34
Artigo
em Inglês
| IMSEAR
| ID: sea-144290
ABSTRACT
Background:
The association of a functional single nucleotide polymorphism at codon 72 of the p53 gene (Arg72Pro) with malignancy is a subject of controversy. We analyzed this polymorphism in 224 patients with gastrointestinal cancers (92 with stomach cancer and 132 with colorectal cancer) and in 163 healthy controls. Material andMethods:
DNA was extracted from peripheral blood mononuclear cells and amplified with an allele-specific polymerase chain reaction.Results:
There was no significant association between p53 alleles and gastrointestinal cancers. The frequency of the Arg allele was 59.7, 58.8, and 59.2% in the stomach cancer patients, colorectal cancer patients, and controls, respectively. Frequencies of the Pro allele were 40.3% in patients with stomach cancer, 41.2% in patients with colorectal cancer, and 40.8% in controls. Likewise, genotype frequencies did not differ significantly between the two patient groups and controls. There were no differences in genotype or allele frequencies by gender, age, or histological grade.Conclusions:
The data do not support the association of the p53 codon 72 polymorphism with stomach or colorectal cancers in Iranian patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias Gástricas
/
Feminino
/
Humanos
/
Masculino
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Reação em Cadeia da Polimerase
/
Proteína Supressora de Tumor p53
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2010
Tipo de documento:
Artigo
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