Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer.

ABSTRACT

Background: Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention. Materials and Methods: In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool. Results: According to this study, 10 strong possible ligands were identified. Conclusion: These sites can be useful for further drug development studies.