Hepatoblastoma: Experience from a single center.
Indian J Cancer
;
2010 Jul-Sept; 47(3): 314-316
Artigo
em Inglês
| IMSEAR
| ID: sea-144357
ABSTRACT
Background:
The cornerstones of successful treatment of hepatoblastoma (HB) include preoperative chemotherapy followed by complete anatomical resection of tumor, followed by chemotherapy. Advances in chemotherapy in the last 2 decades have been associated with a higher rate of tumor response and possibly a greater potential for resectability.Aims:
We analyzed our single center experience with neoadjuvant chemotherapy (NACT) and surgery in HBs. Settings andDesign:
Our study included all children with HBs who received NACT and underwent surgical excision from January 1997 to July 2004. Materials andMethods:
Patient characteristics, clinical features, clinical course, treatment modalities, and long-term outcome were analyzed.Results:
There were 9 boys and 3 girls, aged 5-60 months (median age at tumor diagnosis was 24 months). All received NACT containing cisplatin and doxorubicin. Of the 12 children, 9 underwent hepatectomy and among them, 4 patients each had right and left hepatectomy and 1 patient underwent right extended hepatectomy. After surgery, all patients completed rest of the chemotherapy course (total 6 cycles). R0 resection was carried out in all the 9 cases with no life-threatening complications.Conclusions:
Our experience of the 9 cases, although less in number, reaffirms the advantages of NACT followed by surgery. The prognosis for patients with resectable tumors is fairly good in combination with chemotherapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Feminino
/
Humanos
/
Masculino
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Doxorrubicina
/
Pré-Escolar
/
Seguimentos
/
Cisplatino
/
Resultado do Tratamento
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2010
Tipo de documento:
Artigo
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