Association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population.
Indian J Cancer
;
2010 Jul-Sept; 47(3): 317-321
Artigo
em Inglês
| IMSEAR
| ID: sea-144358
ABSTRACT
Background:
The allele frequency of the multidrug resistance 1 (MDR1) gene C3435T polymorphism differs with different ethnic populations, such as Asian, African, and Caucasian. This polymorphism has been reported to be associated with the increase of gastric cancer.Objectives:
The objective of this study was to find out the association of gastric cancer incidence with MDR1 gene polymorphism in an ethnic Iranian population. Materials andMethods:
In this study, 48 gastric cancer patients were diagnosed. Genomic DNA was extracted by a salting-out method. The MDR1 polymorphism was studied by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method, using a standard method.Results:
The polymorphic homozygote (T/T) genotype showed significantly an association with the incidence of gastric cancer compared with controls (P < 0.05).Conclusions:
This study suggests that C3435T polymorphism of the MDR1 gene may be associated with gastric cancer in an ethnic Iranian population.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Neoplasias Gástricas
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Análise Mutacional de DNA
/
Adenocarcinoma
/
Etnicidade
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2010
Tipo de documento:
Artigo
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