Janus Activated Kinase inhibition in Myelofibrosis.
Indian J Cancer
;
2012 Jul-Sept; 49(3): 260-265
Artigo
em Inglês
| IMSEAR
| ID: sea-144583
ABSTRACT
Janus Activated Kinase (JAK) 2 plays an important role in the pathogenesis of myelofibrosis (MF). Ruxolitinib (INCB018424, Jakafi) is a potent dual JAK1 and JAK2 inhibitor. In November 2011, it became approved by the US FDA for the treatment of intermediate or high-risk MF. This review shall outline the role of Ruxolitinib in the current management of MF and its potential future.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pirazóis
/
Humanos
/
Janus Quinase 1
/
Janus Quinase 2
/
Mielofibrose Primária
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2012
Tipo de documento:
Artigo
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