Glaucomatous neurodegeneration An eye on tumor necrosis factor-alpha.
Indian J Ophthalmol
;
2012 Jul-Aug; 60(4): 255-261
Artigo
em Inglês
| IMSEAR
| ID: sea-144849
ABSTRACT
Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively investigated. Tumor necrosis factor-α, a cytokine, has been recognized to play an important role in pro and antiapoptotic cellular events. In this paper we review the relevant literature to understand (1) The association of increased expression of tumor necrosis factor-α with glaucomatous neurodegeneraion, (2) Modulation of tumor necrosis factor-α expression by exposure to various risk factors of glaucoma, (3) Downstream cellular signaling mechanisms following interaction of tumor necrosis factor-α with its receptors and (4) Role of tumor necrosis factor-α as a possible target for therapeutic intervention in glaucoma. Literature was reviewed using PubMed search engine with relevant key words and a total of 82 English language papers published from 1990 to 2010 are included in this review.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Células Ganglionares da Retina
/
Humanos
/
Literatura de Revisão como Assunto
/
Oclusão da Artéria Retiniana
/
Glaucoma
/
Citocinas
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
PubMed
/
Pressão Intraocular
Tipo de estudo:
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Ophthalmol
Ano de publicação:
2012
Tipo de documento:
Artigo
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