Nephroprotective role of salacia chinensis in diabetic CKD patients: A pilot study.
Indian J Med Sci
;
2010 Aug; 64(8) 378-384
Artigo
em Inglês
| IMSEAR
| ID: sea-145556
ABSTRACT
Background:
Present study aimed to study effect of Salacia Chinensis, a herbal drug, on stabilization of renal functions, and markers of endothelial dysfunction in diabetic chronic kidney disease (CKD) patients. Materials andMethods:
30 stable diabetic CKD patients were randomized into 2 groups; group A and B of 15 patients each. Group A was given trial drug Salacia chinensis 1000 mg twice-daily while group B received placebo. Measures of renal function Serum creatinine and creatinine clearance; markers of endothelial dysfunction Interleukin-6 and serum Homocysteine, and lipid profile were measured at baseline and during follow-up period of 6 months.Results:
There was stabilization of renal function as measured by serum creatinine and creatinine clearance in patients who received Salacia Chinensis compared to placebo (P value < 0.05), suggesting that Salacia chinensis may retard the progression of chronic kidney disease. Similarly, there was significant decline in both serum homocysteine and IL-6 levels. [P value < 0.05 for both].Conclusion:
This pilot study showed a promising role for Salacia chinensis as a renoprotective drug, but further prospective studies involving large number of patients are needed to confirm this and also to delineate possible mechanisms.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Medicamentos de Ervas Chinesas
/
Extratos Vegetais
/
Projetos Piloto
/
Fármacos Neuroprotetores
/
Adulto
/
Medicina Herbária
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS