Immuno-localization of glucose transporter 4 in healthy human gingiva.
Artigo
em Inglês
| IMSEAR
| ID: sea-145783
ABSTRACT
Background:
The gingiva has been shown to be a target tissue for several hormones. Insulin induces uptake of glucose in the peripheral tissues by upregulating the Glucose transporter 4 expression. Little information is available on the expression of Glucose transporter 4 in human gingiva.Aim:
In this regard, a pilot study was performed with the aim of determining the distribution pattern of Glucose transporter 4 in healthy human gingiva. Materials andMethods:
Immuno-histochemistry was performed on 10 mounted sections of healthy human gingiva with the primary antibody Glucose Transporter 4 (GLUT 4). Appropriate positive and negative controls were used.Results:
Glucose transporter 4 expression was observed in the basal and suprabasal layers of the gingival epithelium and fibroblasts of the gingival connective tissue.Conclusion:
This may be the first study to demonstrate the expression of GLUT 4 in the healthy human gingiva. The results of this study raise the possibility that gingiva may serve as a target tissue for insulin action.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Imuno-Histoquímica
/
Transportador de Glucose Tipo 4
/
Gengiva
/
Glucose
/
Insulina
Idioma:
Inglês
Ano de publicação:
2012
Tipo de documento:
Artigo
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