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Pharmacodynamic interaction of garlic with hydrochlorothiazide in rats.
Indian J Physiol Pharmacol ; 2009 Apr-June; 53(2): 127-136
Artigo em Inglês | IMSEAR | ID: sea-145917
ABSTRACT
The purpose of current study was to evaluate the influence of hydrochlorothiazide (HCTZ) on protective effects of garlic homogenate (GH) in rats subjected to myocardial damage induced by ischemia-reperfusion (IRI) and isoproterenol (ISO). Female Wistar albino rats were treated with GH at three different doses of 125; 250 and 500 mg/kg orally for 30 days and HCTZ (10 mg/kg, p.o.) was incorporated in the interactive groups during the last seven days of GH treatment. At the end of treatment, animals were subjected to IRI or ISO induced myocardial damage in their respective models. The GH 250 mg/kg was found to dislodge the effect of ISO and IRI on superoxide dismutase & catalase and retained the activities of LDH and CK-MB. Adding HCTZ improved biochemical, antioxidant and histological status of myocardium during myocardial damage. Since no toxic effects were observed, HCTZ may safely be used to improve GH therapy.

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Idioma: Inglês Revista: Indian J Physiol Pharmacol Ano de publicação: 2009 Tipo de documento: Artigo