Gender differences in alcohol-induced oxidative stress and altered membrane properties in erythrocytes of rats.
Indian J Biochem Biophys
;
2013 Feb; 50(1): 32-39
Artigo
em Inglês
| IMSEAR
| ID: sea-147284
ABSTRACT
Alcohol-induced oxidative stress leads to imbalance between reactive oxygen species (ROS) and the antioxidant defense system, resulting in oxidative damage to membrane components such as lipids and proteins, ultimately altering membrane properties. In this study, we assessed oxidative stress status and alterations in erythrocyte membrane properties in alcohol-administered rats with respect to gender difference. Alcohol (20% v/v) administered rats of both genders showed significant changes in plasma lipid profile with elevated nitrite/nitrate levels. Furthermore, alcohol-administration significantly decreased erythrocyte antioxidant enzymes and enhanced erythrocyte membrane lipid peroxidation, cholesterol/phospholipid (C/P) ratio and Na+/K+-ATPase activity in both males and females. Besides, anisotropic studies revealed that alcohol-administration significantly decreased erythrocyte membrane fluidity. In conclusion, alcohol- administration significantly increased oxidative stress by decreasing antioxidant status, and subsequent generation of ROS altered membrane properties by altering fluidity and Na+/K+-ATPase activity. Female rats were more vulnerable to alcohol-induced biochemical and biophysical changes in plasma and erythrocyte including oxidative stress than male rats.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Feminino
/
Masculino
/
Fatores Sexuais
/
Administração Oral
/
Espécies Reativas de Oxigênio
/
Ratos Wistar
/
Estresse Oxidativo
/
Etanol
/
Membrana Eritrocítica
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2013
Tipo de documento:
Artigo
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