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Preputial gland activates olfactory receptor neurons in rat: Calcium imaging study using laser scanning confocal microscopy.
Indian J Biochem Biophys ; 2013 Jun; 50(3): 242-246
Artigo em Inglês | IMSEAR | ID: sea-147311
ABSTRACT
The rodent preputial gland is one of the major sources of odours and is reported to be involved in several behavioural activities. However, how the preputial gland initiates the olfactory response to manifest the effects is not known. Olfactory receptor neurons (ORNs) present in the olfactory epithelium are involved in the perception of odorant/pheromonal compounds. In the present study, the response of rat ORNs to preputial gland extract was evaluated by calcium imaging analysis. We found that some rat ORNs responded to the preputial gland extract by exhibiting an intracellular calcium response. By contrast, the ORNs did not respond at all to the foot pad extract (control). The results indicated that the substances contained in the preputial gland might interact with a type of receptor expressed in the female rat ORNs, suggested to manifest the behavioural responses, such as social and sexual interactions. This study provided the first evidence of activation of ORNs by the preputial gland extract.
Assuntos

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Potenciais de Ação / Feminino / Masculino / Ratos Wistar / Neurônios Receptores Olfatórios / Microscopia Confocal / Sinalização do Cálcio / Glândulas Exócrinas / Imagens com Corantes Sensíveis à Voltagem Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Ratos / Potenciais de Ação / Feminino / Masculino / Ratos Wistar / Neurônios Receptores Olfatórios / Microscopia Confocal / Sinalização do Cálcio / Glândulas Exócrinas / Imagens com Corantes Sensíveis à Voltagem Idioma: Inglês Revista: Indian J Biochem Biophys Ano de publicação: 2013 Tipo de documento: Artigo