Behcet's disease in India: A dermatological perspective.
Indian J Dermatol Venereol Leprol
;
2013 Mar-Apr; 79(2): 199-204
Artigo
em Inglês
| IMSEAR
| ID: sea-147427
ABSTRACT
Background:
Behcet's disease (BD) is a chronic, recurrent, multi-system inflammatory disorder involving mucocutaneous (MC), ocular, intestinal, articular, vascular, urogenital and neurologic systems. BD occurs with a high prevalence in the Mediterranean population. There is scarcity of clinical data on BD from India with only three case series in the last two decades.Aims:
To study demographic profile, clinical manifestations and treatment outcome of patients with BD presenting to the dermatologic clinic in a tertiary hospital in north India.Methods:
Prospective analysis of all patients diagnosed to have BD between 1997 to 2011.Result:
Twenty nine patients were diagnosed to have BD. The disease had a female preponderance (MF = 13.8) with a mean age of disease onset of 27.4 (range 16-61) years. The prevalence of various MC and systemic manifestations are as follows oral aphthae (100%), genital aphthae (93.1%), erythema nodosum (62%), papulopustular and acneiform lesions (31%), articular involvement (68.9%), ocular involvement (31%) and gastrointestinal (GI) involvement (3.4%) . Pathergy test positivity was observed in 31%. The treatment comprised of colchicine (16/29 patients), dapsone (7/29), dapsone with pentoxiphylline (3/29), systemic steroid (2/29), systemic steroid with methotrexate (1/29). Colchicine was effective and well tolerated in all patients.Conclusion:
The disease occurs in a much milder form in India and is primarily mucocutaneous and arthritic. A high index of suspicion in patients with MC lesions may result in early diagnosis, management and prevention of complications of BD. We suggest colchicine as an effective and safe therapeutic option for MC and joint involvement.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Esteroides
/
Feminino
/
Humanos
/
Masculino
/
Colchicina
/
Síndrome de Behçet
/
Estudos Prospectivos
/
Adolescente
/
Adulto
/
Adulto Jovem
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2013
Tipo de documento:
Artigo
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