Newer targeted therapies in psoriasis.
Indian J Dermatol Venereol Leprol
;
2013 July; 79 Suppl(): S47-52
Artigo
em Inglês
| IMSEAR
| ID: sea-147531
ABSTRACT
Psoriasis is a common, chronic, inflammatory skin disease that can have a significant impact on the quality of life of those who are afflicted due to chronicity of the disease and frequent remissions and relapses. Many available systemic therapies, however, are unsuitable for chronic administration due to the risk of cumulative toxicity. Recent advances in the understanding of the pathophysiology of psoriasis have led to the development of new, genetically engineered, targeted therapies for this disease. These include approaches targeting antigen presentation and co-stimulation, T-cell activation and leukocyte adhesion, action on pro-inflammatory mediators, and modulating the cytokine balance. Although only preliminary data are available so far and there is limited data supporting their use, these trials contribute to a further understanding of the disease and will eventually lead to new therapeutic options for psoriasis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Psoríase
/
Proteínas Recombinantes de Fusão
/
Humanos
/
Calcitriol
/
Transdução de Sinais
/
Citocinas
/
Receptores de Quimiocinas
/
Terapia de Alvo Molecular
/
Anticorpos Monoclonais Humanizados
/
Células Apresentadoras de Antígenos
Idioma:
Inglês
Revista:
Indian J Dermatol Venereol Leprol
Ano de publicação:
2013
Tipo de documento:
Artigo
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