Effect of Vanillin on lipid profile in a model of hyperlipidemia, a preliminary study.
Indian J Exp Biol
;
2013 Apr; 51(4): 288-291
Artigo
em Inglês
| IMSEAR
| ID: sea-147594
ABSTRACT
To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant at 200 and 400 mg/kg doses compared to hyperlipidemic control. The results demonstrate that vanillin at a dose of 200 and 400 mg/kg body weight lowers the serum triglyceride, VLDL-C and total cholesterol level significantly in high fat diet induced hyperlipidemic rats. However there was no significant effect on the lipid profile at 100 mg/kg dose. There were no statistically significant changes in the HDL-C and LDL-C levels at any of the given doses.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxigênio
/
Pirróis
/
Ratos
/
Triglicerídeos
/
Benzaldeídos
/
Feminino
/
Masculino
/
Gorduras na Dieta
/
Regulação da Expressão Gênica
/
Colesterol
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2013
Tipo de documento:
Artigo
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