Derivative chromosome 11 in a child resulting from a complex rearrangement involving chromosomes 3, 6 and 11 in father: Significance of parental karyotyping.
Indian J Hum Genet
;
2013 Apr; 19(2): 262-265
Artigo
em Inglês
| IMSEAR
| ID: sea-149439
ABSTRACT
The presence of derivative chromosome in a child with phenotypic features necessitates the need of parental karyotyping to ascertain the exact amount of loss or gain of the genetic material. The aim of this study was to emphasize the importance of parental karyotyping. Cytogenetic evaluation of the proband and his father were carried out at Laboratory. Cytogenetic analysis was performed on phytohemagglutinin stimulated cultures. The derivative chromosome 11 in proband was ascertained to have additional material from chromosome 6p arising from complex chromosomal rearrangement in the father. Karyotyping is the basic, cost-effective preliminary investigation in a child with mental subnormality or congenital anomalies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Translocação Genética
/
Cromossomos Humanos Par 3
/
Cromossomos Humanos Par 6
/
Cromossomos Humanos Par 11
/
Humanos
/
Masculino
/
Pré-Escolar
/
Adulto
/
Aconselhamento Genético
/
Deficiência Intelectual
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2013
Tipo de documento:
Artigo
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