Henoch-Schonlein purpura: the Chandigarh experience.
Indian Pediatr
;
1998 Jan; 35(1): 19-25
Artigo
em Inglês
| IMSEAR
| ID: sea-14982
ABSTRACT
OBJECTIVE:
To determine the clinical profile of children with Henoch-Schonlein purpura (HSP).DESIGN:
Hospital based descriptive follow-up study.SUBJECTS:
45 patients attending the Pediatric Rheumatology and Immunology clinic over the last 4 years.RESULTS:
The patients were aged between 2.5-12 years with a male to female ratio of 21. All cases had palpable purpura. Gastrointestinal involvement was seen in 38 patients, with abdominal pain in 35 (78%) and lower GI bleed in 21 (47%). Large joint arthritis occurred in 60%. Renal involvement was seen in 14 subjects (31%). Major renal involvement occurred in 9 patients, with nephritic syndrome in 6 and nephrotic syndrome in 3 cases. Five patients had minor urinary abnormalities; 6 patients with major renal involvement and crescentic glomerulonephritis were treated with high dose pulse steroid therapy followed by oral prednisolone and azathioprine for 12-18 months. Normalization of urinary abnormalities occurred in these patients over 4-8 months and presently all are normotensive and off antihypertensive drugs.CONCLUSIONS:
HSP in children is a common form of vasculitis. Though short term results in HSP nephritis have been good, long term prognosis in those with major renal involvement would remain guarded.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Vasculite por IgA
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Adolescente
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1998
Tipo de documento:
Artigo
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