Inflammation and MMPs in alcohol-induced liver diseases and protective action of antioxidants.
Indian J Biochem Biophys
;
2013 Oct; 50(5): 377-386
Artigo
em Inglês
| IMSEAR
| ID: sea-150247
ABSTRACT
The consumption of alcohol causes several liver-associated diseases all over the world. Alcoholic liver diseases (ALD) include hepatic inflammation, fatty liver, hepatitis, liver cirrhosis and fibrosis and finally hepatocellular carcinoma. Although the cellular, metabolic and biochemical mechanisms for these diseases are quite explicable, the roles of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are still under investigation. The present review describes the roles and regulation of MMPs and TIMPs in different ALDs along with the involvement of other pathways. This review also summarizes the present knowledge on clinical and experimental trials with different antioxidants that help against alcohol associated liver diseases.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Citoproteção
/
Metaloproteinases da Matriz
/
Inflamação
/
Hepatopatias Alcoólicas
/
Antioxidantes
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2013
Tipo de documento:
Artigo
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