Quercetin and β-sitosterol prevent high fat diet induced dyslipidemia and hepatotoxicity in Swiss albino mice.
Indian J Exp Biol
;
2014 Jan; 52(1): 60-66
Artigo
em Inglês
| IMSEAR
| ID: sea-150333
ABSTRACT
High fat diet group showed a significant rise in serum and hepatic total cholesterol, triglyceride and atherogenic index which are major biomarkers of dyslipidemia and cardiovascular risk. The liver function markers, lipid peroxidation and proinflammatory cytokine levels were elevated in high fat diet group whereas antioxidant levels significantly reduced. These findings manifest hepatic damage which was further confirmed by histological findings. Quercetin and β-sitosterol though structurally different yet both ameliorate the sickening changes in different mechanism. The current investigation is perhaps the first report of the mechanistic role of two polyphenols over dyslipidemia and subsequent hepatotoxicity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Quercetina
/
Sitosteroides
/
Triglicerídeos
/
Doenças Cardiovasculares
/
Peroxidação de Lipídeos
/
Dislipidemias
/
Dieta Hiperlipídica
/
Lipídeos
/
Fígado
/
Animais
Idioma:
Inglês
Revista:
Indian J Exp Biol
Ano de publicação:
2014
Tipo de documento:
Artigo
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