Synthesis and antimicrobial studies of substituted 2-phenylbenzimidazole derivatives.

ABSTRACT

The substituted 2-phenylbenzimidazole derivatives were synthesized by introducing different substituents at different positions. Six novel benzimidazole derivatives were synthesized successfully in appreciable yields and characterized physicochemically. The structures of all the synthesized derivatives were confirmed by IR and 1HNMR. Furthermore, the synthesized compounds were screened for antimicrobial activity (antibacterial activity and antifungal activity) by tube dilution method. Some of the synthesized compounds showed appreciable antifungal activity.