Subtherapeutic Dose of Prazosincan Ameliorate Metformin Induced Lactic Acidosis in Renal Compromised Rats.

ABSTRACT

Incidence of lactic acidosis caused by metformin is rare but this can occur in renal compromised individuals because of metformin accumulation. The drug enters the liver through organic cationic transporter 1(OCT1) and reduces oxygen consumption in mitochondria resulting in reduced lactate clearance and lactic acidosis. In the present study, we investigated that inhibition of the transport of metformin in the liver could reduce the blood lactate levels. Eighteen healthy male albino rats were selected for the study. Group 1- control group included 6 rats, they were given normal saline for 10 days by i.p injection. Group 2- Twelve rats were induced nephrotoxicity by gentamicin at the doses of 40mg/kg given by i.p. route . Group 3- six rats from group 2 were given metformin according to human doses of 1000mg/day and group 4- included six rats from group 2 received metformin and prazosin at subtherapeutic dose i.e. according to 1mg/day human dose. Blood urea, serum creatinine and total urinary albumin were found to be significantly.