Ameliorative Effects of Magnesium and Copper Sulphates on Blood glucose and Serum Electrolytes Levels in Fructose-induced Diabetic Wistar Rats.

ABSTRACT

The aim of this study is to evaluate the effects of magnesium and copper sulphates on blood glucose and serum electrolytes levels in fructose-induced diabetic Wistar rats. Diabetes was induced by administration of 20% (20g/100ml) of fructose dissolved in distilled water and administered to the animals for a period of six (6). After which the animals were randomly assigned into 4 groups of 6 rats each. Group I served as diabetic control and were administered distilled water, Group II were administered Magnesium sulphate (250 mg/kg b w), Group III were administered Copper sulphate (250 mg/kg b w) and Group IV administered Metformin (250 mg/kg b w). All treatments were given orally for a period of seven days. The results obtained showed a statistically significant decrease (p<0.05) in the blood glucose levels in groups administered with 250 mg/kg b w of magnesium and copper sulphate after day 3 and 7 when compared to diabetic control group. The results also showed that magnesium and copper sulphates at doses tested i.e 250 mg/kg b w, produced a significantly decreased (p<0.05). With regard to serum levels of sodium, potassium and bicarbonate ions when compared to diabetic untreated control group. However, there was no significant difference in the levels of serum chloride in the groups treated with 250mg/kg b w of magnesium and copper sulphate when compared to diabetic control group.