Antiulcer effect of Feronia elephantum Correa leaf and bark extract in indomethacin induced albino rats.

ABSTRACT

In the present study, the gastro protective effect of Feronia elephantum leaves and bark in a model of NSAIDinduced ulcer in rat was analyzed. The lyophilized extract was given by oral gavages (500 mg/kg) three times at 12 hr intervals before administering Indomethacin at 20 mg/kg. Pretreatment with extract significantly decreased the ulcerated area. The volume and acidity of the gastric juice decreased in the pretreated rats. In conclusion, F. elephantum was able to decrease the acidity and increase the mucosal defense in the gastric areas, there by justifying its use as an antiulcerogenic agent.