Extensive osteomyelitis of humerus following Bacille Calmette-Guérin vaccination.

ABSTRACT

Bacille Calmette-Guérin (BCG) vaccination administered at birth can lead to certain complications which may present immediate or late. We report a rare case of BCG osteomyelitis in a nine months old immunocompetent female child with extensive destruction of middle and distal third of humerus sparing the proximal bone. Surgical debridement revealed casseous material and dead bone. Biopsy showed inflammatory tissue containing Langhan’s giant cells and granulomatous inflammatory infiltrate. Culture was suggestive of BCG osteomyelitis. Anti-tubercular chemotherapy favoured betterment of her condition and the child has no signs of infection after one year.