Coronary artery bypass grafting in a patient with protein S deficiency: Perioperative implications.
Ann Card Anaesth
;
2014 Jul; 17(3): 232-236
Artigo
em Inglês
| IMSEAR
| ID: sea-153677
ABSTRACT
Protein S (PS) along with activated protein C plays an important role in the down-regulation of in vivo thrombin generation. Its defi ciency can cause abnormal and inappropriate clot formation within the circulation necessitating chronic anticoagulation therapy. The risk of developing thrombotic complications is heightened in the perioperative period in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Heparin resistance is very rare in these patients, especially when antithrombin levels are near normal. Management of CPB in this scenario is quite challenging. We report the perioperative management, particularly the CPB management, of a patient with type I PS defi ciency and incidentally detected heparin resistance, who underwent coronary artery bypass grafting with CPB.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Masculino
/
Resistência a Medicamentos
/
Heparina
/
Ponte Cardiopulmonar
/
Ponte de Artéria Coronária
/
Deficiência de Proteína S
/
Trombofilia
/
Assistência Perioperatória
/
Pessoa de Meia-Idade
Idioma:
Inglês
Revista:
Ann Card Anaesth
Ano de publicação:
2013
Tipo de documento:
Artigo
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