CD44: A key player in breast cancer.
Indian J Cancer
;
2014 Jul-Sep; 51(3): 247-250
Artigo
em Inglês
| IMSEAR
| ID: sea-154367
ABSTRACT
CD44 is a principal transmembrane hyluronate receptor, which acts as a hook between Extracellular Matrix and the cytoskeleton. CD44 is up regulated in breast cancer, which in turn helps in tumor progression and metastasis. There has been a lot of attention given to CD44 in recent years because of the discovery, CD44+/CD24- lineage marks breast cancer stem cells. Recent clinical and experimental findings show that CD44 is involved in the tumor associated proliferation, invasion, migration, and in many pathways involved in maintaining cancer cells which inturn are correlated with patient's survival. All these findings make CD44 as a potential target for breast cancer treatment. The methods of literature search for this article include Pubmed, BMC cancer and other printed journal article.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias da Mama
/
Humanos
/
Receptores de Hialuronatos
/
Ácido Hialurônico
Idioma:
Inglês
Revista:
Indian J Cancer
Ano de publicação:
2014
Tipo de documento:
Artigo
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