Free oxygen radicals in acute renal failure.
Indian Pediatr
;
2000 Feb; 37(2): 153-8
Artigo
em Inglês
| IMSEAR
| ID: sea-15446
ABSTRACT
OBJECTIVE:
To assess the levels of free oxygen radicals in acute renal failure and their predictive value in clinical outcome.DESIGN:
Prospective.SETTING:
Intensive care unit.METHODS:
Study was conducted in 50 children (25 with acute renal failure and 25 age and sex matched controls). Blood urea, serum creatinine, serum protein, uric acid and free oxygen radical markers were estimated in both groups. Superoxide dismutase (SOD), glutathione peroxidase(GPx) and lipid peroxide (LPO) were estimated in blood by standard techniques.RESULTS:
Hemolytic uremic syndrome (HUS) was a major cause of acute renal failure (52%), rest were due to acute glomerulonephritis (AGN), septicemia and renal venous thrombosis. In the renal failure group 56% of the patients were dialyzed (peritoneal) and the mortality was 28% (7/25). The levels of SOD, GPx and LPO were significantly raised in renal failure group. Higher values of LPO, SOD and GPx were documented in subjects who expired. The most important independent variable for predicting clinical outcome was LPO with a sensitivity of 89.4%, specificity of 93%, positive predictive value of 95%.CONCLUSION:
Levels of free oxygen radicals (SOD, LPO and GPx) are raised in acute renal failure and these enzymes can be used as marker of renal injury. LPO levels are highly sensitivity and specific for predicting the clinicaloutcome:
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredutases
/
Feminino
/
Humanos
/
Masculino
/
Biomarcadores
/
Estudos de Casos e Controles
/
Criança
/
Pré-Escolar
/
Análise Multivariada
/
Taxa de Sobrevida
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2000
Tipo de documento:
Artigo
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