Evaluation of immunogenicity and tolerability of a live attenuated hepatitis a vaccine in Indian children.
Indian Pediatr
;
2006 Nov; 43(11): 983-7
Artigo
em Inglês
| IMSEAR
| ID: sea-15498
ABSTRACT
An open non comparative study of a live attenuated H2 strain Hepatitis A vaccine of Chinese origin was carried out in 143 healthy Indian children aged 1 to 12 years (mean age 4.87 2.76 years; 88 boys, 55 girls). At baseline, all were negative for IgG HAV antibodies and had normal hematological and biochemical indices. Two months after a single dose of the vaccine (given subcutaneously), 137 children (i.e. 95.8 %) developed protective antibodies of IgG > 20 mIU / mL. The hematological and biochemical parameters remained within normal limits. There were no adverse events in any except mild fever in one child. In conclusion, live attenuated H2 strain Hepatitis A vaccine in a single dose was found to be immunogenic and safe in Indian children.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Segurança
/
Feminino
/
Humanos
/
Masculino
/
Imunoglobulina G
/
Vacinas Atenuadas
/
Criança
/
Pré-Escolar
/
Anticorpos Anti-Hepatite C
/
Vacinas contra Hepatite A
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2006
Tipo de documento:
Artigo
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