Regulation of N-Myristoyltransferase by the Calpain and Caspase Systems.
Indian J Biochem Biophys
;
2014 Dec ; 51(6): 506-511
Artigo
em Inglês
| IMSEAR
| ID: sea-156530
ABSTRACT
N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathways. In higher eukaryotes, two isoforms of NMT have been identified (NMT1 and NMT2) which share about 76% amino acid sequence identity in humans. Protein-protein interactions of NMTs reveal that m-calpain interacts with NMT1 whereas caspase-3 interacts with NMT2. These findings reveal differential interactions of both isoforms of NMT with various signaling molecules. This minireview provides an overview of the regulation of N-myristoyltransferase by calpain and caspase systems.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Aciltransferases
/
Calpaína
/
Transdução de Sinais
/
Regulação Enzimológica da Expressão Gênica
/
Caspases
/
Metabolismo dos Lipídeos
/
Animais
/
Modelos Biológicos
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2014
Tipo de documento:
Artigo
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