Usage of U7 small nuclear ribonucleic acid in gene therapy of hemoglobin D Punjab disorder: Rationale.
Indian J Hum Genet
;
2013 July-Sept ;19 (3): 291-292
Artigo
em Inglês
| IMSEAR
| ID: sea-156572
ABSTRACT
BACKGROUND:
Hemoglobin (Hb) D Punjab disorder is a congenital hemoglobinopathy described in India. It is a disorder due to defect in beta-globin gene. MATERIALS ANDMETHODS:
Here, the author assesses the possibility of U7.623 gene therapy for Hb D Punjab disorder. A standard bioinformatic analysis to study the effect of co-expression between nucleic acid sequence for human Hb D Punjab beta-globin chain and U7.623 was performed.RESULT:
It can be seen that fully recovery of Hb function and biological process can be derived via gene ontology study.CONCLUSION:
Here, there is a rationale to use U7 small nuclear ribonucleic acid as a possible tool for gene therapy in Hb D Punjab disorder.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Hemoglobinas Anormais
/
Terapia Genética
/
Biologia Computacional
/
Ribonucleoproteína Nuclear Pequena U7
/
PubMed
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2013
Tipo de documento:
Artigo
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