Genetic variants in the cytochrome P450 2D6 gene in the Sri Lankan population.
Indian J Hum Genet
;
2013 Oct-Dec ;19 (4): 392-396
Artigo
em Inglês
| IMSEAR
| ID: sea-156602
ABSTRACT
INTRODUCTION:
Cytochrome P450 2D6 (CYP2D6) enzymes are involved in the metabolism of a large number of commonly prescribed drugs such as antidepressants and cardiovascular drugs. The CYP2D6 *3, *4 and *14 variants associated with the loss of enzyme function; CYP2D6 *10 and *17 variants with reduced enzyme function; and CYP2D6 *2 variant with no effect on enzyme function. Establishing the frequency of these variant alleles in Sri Lankan population would be useful for optimizing pharmacotherapy with CYP2D6‑substrate drugs.OBJECTIVE:
The objective of this study was to determine the prevalence of CYP2D6 *2, *3, *4, *10, *14 and *17 variants in the main ethnic groups in the Sri Lankan population. MATERIALS ANDMETHODS:
A total of 90 deoxyribonucleic acid (DNA) samples (30 each from Sinhalese, Tamils and Moors) were selected from a DNA resource at the Human Genetic Unit, Faculty of Medicine, University of Colombo. This collection had been made for population genetic studies from a random population based volunteers. Genotyping was performed using published polymerase chain reaction/ restriction fragment length polymorphism methods.RESULTS:
The prevalence of the CYP2D6 variants in Sinhalese, Sri Lankan Tamils and Moors respectively were CYP2D6 *2 37%, 41.6% and 37.9%; CYP2D6 *3 60.3%, 45% and 30%; CYP2D6 *4 21.6%, 6.6% and 8.3%; CYP2D6 *10 40%, 35% and 44%. CYP2D6 *14 and *17 variants were not identified.CONCLUSION:
CYP2D6 *3, *4 and *10 variants, which are associated with reduced or loss of CYP2D6 enzyme function were found in our population in significant frequencies. CYP2D6*4, which is reported to be a Caucasian variant was also found in all three ethnic groups.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sri Lanka
/
Variação Genética
/
Humanos
/
Masculino
/
Citocromo P-450 CYP2D6
/
Grupos Populacionais
/
Povo Asiático
/
Frequência do Gene
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Hum Genet
Ano de publicação:
2013
Tipo de documento:
Artigo
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