Your browser doesn't support javascript.
loading
Association of matrix metalloproteinase -7 (-181A/G) promoter polymorphism in chronic pancreatitis.
Artigo em Inglês | IMSEAR | ID: sea-157087
ABSTRACT
Background &

objectives:

Chronic pancreatitis is progressive and irreversible destruction of the pancreas. Matrix metalloproteinase-7 (MMP-7) is a secreted matrilysin, which contributes to angiogenesis and breakdown of basement membranes of pancreatic tissues. The present study was aimed to investigate the association of MMP-7 −181A/G (rs11568818) gene promoter polymorphism in patients with chronic pancreatitis.

Methods:

A total of 100 chronic pancreatitis patients and 150 unrelated healthy individuals were included in this case control study. The genotyping of the MMP-7 gene (− 181 A/G) (rs11568818) was carried out based on PCR-RFLP. The serum levels of MMP-7 were determined by ELISA. Association between genotypes and chronic pancreatitis was examined by odds ratio (OR) with 95% confidence interval (CI).

Results:

The frequencies of the genotypes in promoter of MMP-7 were AA 49 per cent, AG 25 per cent and GG 26 per cent in chronic pancreatitis patients and AA 53 per cent, AG 38 per cent and GG 9 per cent in control subjects. Frequency of MMP-7 −181GG genotype and − 181G allele was significantly associated with chronic pancreatitis compared to healthy subjects [OR = 1.58 (95% CI 1.06 –2.36), p =0.019]. There was no significant difference in the serum MMP-7 levels in the patients compared to control subjects. Interpretation &

conclusions:

The present study revealed a significant association of MMP-7 -181A/G (rs11568818) GG genotype with chronic pancreatitis patients, indicating its possible association with the disease.
Assuntos

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Feminino / Humanos / Masculino / Estudos de Casos e Controles / Fatores de Risco / Regiões Promotoras Genéticas / Adulto / Predisposição Genética para Doença / Metaloproteinase 7 da Matriz / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Ano de publicação: 2014 Tipo de documento: Artigo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Feminino / Humanos / Masculino / Estudos de Casos e Controles / Fatores de Risco / Regiões Promotoras Genéticas / Adulto / Predisposição Genética para Doença / Metaloproteinase 7 da Matriz / Polimorfismo de Nucleotídeo Único Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Ano de publicação: 2014 Tipo de documento: Artigo