Weak D antigen - Revisited.
Artigo
em Inglês
| IMSEAR
| ID: sea-157332
ABSTRACT
D antigen is the most immunogenic antigen in the complex Rh blood group system discovered in the year 1939. There is a lot of polymorphism in its phenotype due to genetic heterogeneity. Certain mutations and /or deletions lead to a weak phenotype defined by decreased density of antigen sites which require the use of anti human globulin for detection. The need for detection of the weak D antigen was to prevent alloimmunization by this blood if transfused to a D negative patient especially to women in child bearing age group. This contention is however, controversial and not proven beyond doubt. Moreover, the use of potent monoclonal D typing antisera detects low density of weak D antigens thus obviating the use of anti human globulin. We have assessed the incidence of Rh negative and weak D blood groups in the Garhwal region of Uttarakhand and reviewed the literature regarding the controversies in the clinical significance of weak D antigen.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sistema do Grupo Sanguíneo Rh-Hr
/
Isoimunização Rh
/
Feminino
/
Humanos
/
Imunoglobulinas
/
Tipagem e Reações Cruzadas Sanguíneas
/
Incidência
/
Imunização
/
Globulinas
/
Índia
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2011
Tipo de documento:
Artigo
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