Hepatoprotective Effects of Crude Extracts of Tomato and Onion in Rats Exposed to Locally Processed Beef.

ABSTRACT

This study was carried out to examine the hepatoprotective effect of ethylacetate extract of tomatoes and methanol extract of onions on the biochemical changes induced by feed formulated with 15% roasted beef and 85% rats pellets. Doses of 500 mg/kg body weight of both extracts were administered orally. The hepatic activities of aspartate aminotransferase (AST), alanine amino-transferase (ALT) and alkaline phosphatase (ALP) were examined, also concentrations of total protein, albumin and globulin were monitored in the animals. The effects of feeding and treatment on oxidative stress parameters (CAT, SOD, GPx, Glutathione and MDA) were determined. The changes observed were discussed.