Anti-nociceptive and antimicrobial evaluation of mannich bases of 1H-Indoles.

ABSTRACT

A series of several novel mannich bases of indoles (1A-L) have been synthesized from indole by reacting with respective aldehyde and the various compounds containing secondary amine. The synthesized compounds were characterized by IR and 1HNMR spectral analysis. All the synthesized compounds were evaluated for their anti-nociceptive activity in mice by Eddy’s hot plate method. The reaction time was compared with standard drug pentazocine. In vitro antimicrobial activity of the synthesized compounds were screened against the Gram positive microorganisms such as Staphylococcus aureus, Streptococcus pyogenes, Gram negative microorganisms such as Escherchia coli, Klebsiella aerogenes and fungus Candida albicans by cup plate method. The zone of inhibition of the synthesized compounds was compared with the standard drug amikacin and ketoconazole respectively. All the synthesized compounds exhibited significant anti-nociceptive activity and showed moderate antimicrobial activity.