Angiotensin II inhibits Na+/K+ATPase activity in pulmonary artery smooth muscle cells via glutathionylation and with the involvement of a 15.6 kDa inhibitor protein.
Indian J Biochem Biophys
;
2015 Apr; 52 (2): 119-124
Artigo
em Inglês
| IMSEAR
| ID: sea-158207
ABSTRACT
The role of angiotensin II in regulating Na+/K+-ATPase activity has been investigated in bovine pulmonary artery smooth muscle cells (BPASMCs). Our study reveals that angiotensin II inhibits the Na+/K+ATPase activity via glutathionylation of the pump with the involvement of an increase in NADPH oxidase-derived O2.-. Additionally, angiotensin II treatment to the cells increases the inhibitory potency of the 15.6 kDa inhibitor towards the Na+/K+ATPase activity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Oxirredução
/
Artéria Pulmonar
/
Angiotensina II
/
ATPase Trocadora de Sódio-Potássio
/
Inibidores Enzimáticos
/
Glutationa
Idioma:
Inglês
Revista:
Indian J Biochem Biophys
Ano de publicação:
2015
Tipo de documento:
Artigo
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